Seras LOVES her big guns. She has handled sniper rifles, grenade launchers and anti-tank rifles taking down armies of ghouls. She is also able to fly at will and unleash havoc against her enemies with ease after drinking the blood of Pip Bernadotte, the leader of the mercenary outfit "Wild Geese" who fell in love with her and consented to become a part of her during her rechristening as a full-fledged vampire.
She even took down a Nazi fucking werewolf! Also, she survived the assault of the Vatican's Judas Priest, God's Assasin. The bayonet-loving and Boondock Saints-quoting, Alexander Anderson. The only Catholic guy I will EVER respect.